The Look AHEAD Trial: Implications for Lifestyle Intervention in Type 2 Diabetes Mellitus (2024)

1. Jensen, AHA/ACC/TOS guideline for the management of overweight and obesity in adults: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the Obesity Society, J Am Coll Cardiol, № 63, с. 2985
   https://doi.org/10.1016/j.jacc.2013.11.004
2. Field, Epidemiology and health and economic consequences of obesity, с. 3
3. National Heart Lung Blood Institute, Clinical guidelines on the identification, evaluation, and treatment of overweight and obesity in adults: the evidence report
4. Coakley, Lower levels of physical functioning are associated with higher body weight among middle-aged and older women, Int J Obes Relat Metab Disord, № 22, с. 958
   https://doi.org/10.1038/sj.ijo.0800698
5. Fine, A prospective study of weight change and health-related quality of life in women, JAMA, № 282, с. 2136
   https://doi.org/10.1001/jama.282.22.2136
6. Petry, Overweight and obesity are associated with psychiatric disorders: results from the National Epidemiologic Survey on Alcohol and Related Conditions, Psychosom Med, № 70, с. 288
   https://doi.org/10.1097/PSY.0b013e3181651651
7. Zhao, Depression and anxiety among US adults: associations with body mass index, Int J Obes (Lond), № 33, с. 257
   https://doi.org/10.1038/ijo.2008.268
8. Flegal, Cause-specific excess deaths associated with underweight, overweight, and obesity, JAMA, № 298, с. 2028
   https://doi.org/10.1001/jama.298.17.2028
9. Bauer, Prevention of chronic disease in the 21st century: elimination of the leading preventable causes of premature death and disability in the USA, Lancet, № 384, с. 45
   https://doi.org/10.1016/S0140-6736(14)60648-6
10. Knowler, Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin, N Engl J Med, № 346, с. 393
    https://doi.org/10.1056/NEJMoa012512
11. Pan, Prevalence of diabetes and its risk factors in China, 1994. National Diabetes Prevention and Control Cooperative Group, Diabetes Care, № 20, с. 1664
    https://doi.org/10.2337/diacare.20.11.1664
12. Trials of Hypertension Prevention Collaborative Research Group, Arch Intern Med, № 157, с. 657
    https://doi.org/10.1001/archinte.1997.00440270105009
13. Tuomilehto, Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance, N Engl J Med, № 344, с. 1343
    https://doi.org/10.1056/NEJM200105033441801
14. Whelton, Sodium reduction and weight loss in the treatment of hypertension in older persons: a randomized controlled trial of nonpharmacologic interventions in the elderly (TONE). TONE Collaborative Research Group, JAMA, № 279, с. 839
    https://doi.org/10.1001/jama.279.11.839
15. Gregg, The relationship of intertional weight loss to disease incidence and mortality, с. 125
16. Schellenberg, Lifestyle interventions for patients with and at risk for type 2 diabetes: a systematic review and meta-analysis, Ann Intern Med, № 159, с. 543
    https://doi.org/10.7326/0003-4819-159-8-201310150-00007
17. Yanovski, Report of a National Institutes of Health–Centers for Disease Control and Prevention workshop on the feasibility of conducting a randomized clinical trial to estimate the long-term health effects of intentional weight loss in obese persons, Am J Clin Nutr, № 69, с. 366
    https://doi.org/10.1093/ajcn/69.3.366
18. The Look AHEAD Research Group, Look AHEAD (Action for Health in Diabetes): design and methods for a clinical trial of weight loss for the prevention of cardiovascular disease in type 2 diabetes, Control Clin Trials, № 24, с. 610
    https://doi.org/10.1016/S0197-2456(03)00064-3
19. Look Ahead Research Group, The Look AHEAD study: a description of the lifestyle intervention and the evidence supporting it, Obesity (Silver Spring), № 14, с. 737
    https://doi.org/10.1038/oby.2006.84
20. Look Ahead Research Group, Baseline characteristics of the randomized cohort from the Look AHEAD (Action for Health in Diabetes) study, Diab Vasc Dis Res, № 3, с. 202
    https://doi.org/10.3132/dvdr.2006.031
21. Look AHEAD Research Group, Cardiovascular effects of intensive lifestyle intervention in type 2 diabetes, N Engl J Med, № 369, с. 145
    https://doi.org/10.1056/NEJMoa1212914
22. Brancati, Midcourse correction to a clinical trial when the event rate is underestimated: the Look AHEAD (Action for Health in Diabetes) Study, Clin Trials, № 9, с. 113
    https://doi.org/10.1177/1740774511432726
23. Look AHEAD Research Group, Long-term effects of a lifestyle intervention on weight and cardiovascular risk factors in individuals with type 2 diabetes mellitus: four-year results of the Look AHEAD Trial, Arch Intern Med, № 170, с. 1566
24. Unick, The long-term effectiveness of a lifestyle intervention in severely obese individuals, Am J Med, № 126, с. 236
    https://doi.org/10.1016/j.amjmed.2012.10.010
25. Jakicic, Effect of a lifestyle intervention on change in cardiorespiratory fitness in adults with type 2 diabetes: results from the Look AHEAD Study, Int J Obes, № 33, с. 305
    https://doi.org/10.1038/ijo.2008.280
26. Pownall, Changes in body composition over 8 years in a randomized trial of a lifestyle intervention: the Look AHEAD Study, Obesity (Silver Spring), № 23, с. 565
    https://doi.org/10.1002/oby.21005
27. Gregg, Association of an intensive lifestyle intervention with remission of type 2 diabetes, JAMA, № 308, с. 2489
    https://doi.org/10.1001/jama.2012.67929
28. Rubin, Impact of intensive lifestyle intervention on depression and health-related quality of life in type 2 diabetes: the Look AHEAD Trial, Diabetes Care, № 37, с. 1544
    https://doi.org/10.2337/dc13-1928
29. The Look AHEAD Research Group, Effect of a long-term behavioural weight loss intervention on nephropathy in overweight or obese adults with type 2 diabetes: a secondary analysis of the Look AHEAD randomised clinical trial, Lancet Diabetes Endocrinol, № 2, с. 801
    https://doi.org/10.1016/S2213-8587(14)70156-1
30. Breyer, Intensive lifestyle intervention reduces urinary incontinence in overweight/obese men with type 2 diabetes: results from the Look AHEAD trial, J Urol, № 192, с. 144
    https://doi.org/10.1016/j.juro.2014.02.036
31. Phelan, Weight loss prevents urinary incontinence in women with type 2 diabetes: results from the Look AHEAD trial, J Urol, № 187, с. 939
    https://doi.org/10.1016/j.juro.2011.10.139
32. Wing, Effects of weight loss intervention on erectile function in older men with type 2 diabetes in the Look AHEAD trial, J Sex Med, № 7, с. 156
    https://doi.org/10.1111/j.1743-6109.2009.01458.x
33. Espeland, Impact of an intensive lifestyle intervention on use and cost of medical services among overweight and obese adults with type 2 diabetes: the action for health in diabetes, Diabetes Care, № 37, с. 2548
    https://doi.org/10.2337/dc14-0093
34. Rejeski, Aging and physical function in type 2 diabetes: 8 years of an intensive lifestyle intervention, J Gerontol A Biol Sci Med Sci, № 70, с. 343
35. Houston, A long-term intensive lifestyle intervention and physical function: the Look AHEAD Movement and Memory Study, Obesity (Silver Spring), № 23, с. 77
    https://doi.org/10.1002/oby.20944
36. American Diabetes Association, Strategies for improving care, Diabetes Care, № 38, с. S5
    https://doi.org/10.2337/dc15-S004
37. ADVANCE Collaborative Group, Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes, N Engl J Med, № 358, с. 2560
    https://doi.org/10.1056/NEJMoa0802987
38. Duckworth, Glucose control and vascular complications in veterans with type 2 diabetes, N Engl J Med, № 360, с. 129
    https://doi.org/10.1056/NEJMoa0808431
39. Action to Control Cardiovascular Risk in Diabetes Study Group, Effects of intensive glucose lowering in type 2 diabetes, N Engl J Med, № 358, с. 2545
    https://doi.org/10.1056/NEJMoa0802743
40. Unick, Evaluation of early weight loss thresholds for identifying nonresponders to an intensive lifestyle intervention, Obesity (Silver Spring), № 22, с. 1608
    https://doi.org/10.1002/oby.20777
41. Holman, 10-year follow-up of intensive glucose control in type 2 diabetes, N Engl J Med, № 359, с. 1577
    https://doi.org/10.1056/NEJMoa0806470
42. Zoungas, Follow-up of blood-pressure lowering and glucose control in type 2 diabetes, N Engl J Med, № 371, с. 1392
    https://doi.org/10.1056/NEJMoa1407963

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